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We further classified compounds according to the suggested classification of Neves , and Weber and colleagues with adaptions into "original", "substandard" and "counterfeit". Classification of prohibited substances are according to the world anti-doping agency (WADA) prohibited list (Updated version as of 01 January 2021) (Table 2). candy96.fun • articles that present proportions of original and/or counterfeit and/or substandard drugs Disagreements in study eligibility, data extraction, and quality assessment were resolved by consensus between the two reviewers.
AAS were the most dominant group within all analyzed products, and they were almost exclusively analyzed within the WADA class S1. We demonstrate that substantial proportions of AAS found on the black market are fake. Some authors assessed visual inspection of packaging and detection of counterfeiting rate with contradicting results. Some authors have analyzed and compared the quantity and quality of different AAS formulations.
For most original substances, we were able to extract qualitatively analyzed data (accurately labeled) and only for 37% were we able to extract qualitatively and quantitatively analyzed data (accurately labeled and concentration within range as declared on the label). Half of the studies presenting data on substandard substances were sub-analyzed into over-concentrated and under-concentrated samples. In 17 articles we were able to extract samples that exclusively analyzed anabolic agents (WADA class S1). Most samples (74%) originated from seized compounds by the police, custom authorities, or justice departments and a minority of samples were bought directly from the black market or provided by gyms and users themselves. The studies included a median of 42 samples; the largest study had 2818 analyzed samples and the smallest 8 samples, and a cumulative sample size of 5,413 anabolic agents. Characteristics of 19 published studies presenting qualitative and quantitative data of fake AAS on the black-market
After the quality appraisal stage, an overall number of 19 full-text articles were included for data extraction and analysis. All quality appraisal results can be found in Supplementary file 1. A total of 20 full-text articles were included for quality appraisal by the ToxRTool.
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